Fluoroquinolone-Induced Motor Changes in the Guinea-Pig Isolated Ileum
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چکیده
منابع مشابه
Antihistaminic activity of carane derivatives in isolated guinea pig ileum.
Local anesthetics (LAs) inhibit membrane depolarization by reducing sodium and potassium conductance, and subsequent displacement of calcium ions from binding sites seems to occur. Histamine release appears to be a secretory process in which calcium couples the stimulus to the exocytosis of histamine-containing granules. Furthermore, LAs are structurally similar to histamine H(1)-receptor antag...
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Sodium valproate (SV), an antiepileptic drug has several mechanism of action. It inhibits voltage sensitive Na+ channels and reduces intracellular Na accumulation. These actions are similar to that of both phenytoin and carbamazepine. We have investigated the direct cardiac action of SV and its effects on ouabain-induced arrhythmia in isolated guinea-pig atria. The guinea-pig atrium was dissect...
متن کاملPolar innervation of enteric non-cholinergic and non-adrenergic neurons in the isolated guinea-pig ileum.
To study the polarity of the efferent pathway of the myenteric plexus, recordings were made of the mechanical activity of the longitudinal muscle of isolated guinea-pig ileal segments upon stimulation with an electrical field around the myenteric plexus contained within strips of longitudinal muscle (LM-MP) continuous with each end of ileal segment. The amplitude of the contractile response to ...
متن کاملEvidence for A1 adenosine receptor–mediated inhibition of peristalsis in the guinea-pig isolated ileum
Segments of ileum (5-30 cm from the caecum) were obtained from male guinea-pigs (Dunkin Hartley, 300-500g), cannulated at the oral and aboral ends and secured horizontally in 10 ml baths containing Krebs’ solution maintained at 37oC and oxygenated with 95%O2 and 5%CO2. Regular peristalsis was obtained by infusing saline solution into the lumen using the method described previously (Costall et a...
متن کاملEffects of capsaicin on the circular muscle motility of the isolated guinea-pig ileum.
Effects of capsaicin on the circular muscle motility of the isolated guinea-pig ileum were investigated. Capsaicin produced a contraction followed by a relaxation of the circular muscle. Both responses were easily desensitized. As the late relaxation response was not sufficiently intense to be analyzed, the inhibitory effect of capsaicin on substance P-induced contractions was explored. Capsaic...
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ژورنال
عنوان ژورنال: Pharmacology & Toxicology
سال: 1998
ISSN: 0901-9928,1600-0773
DOI: 10.1111/j.1600-0773.1998.tb01480.x